Rune world is a high fantasy setting of my creation and slowly evolving as our games are being played.
In this world, the gods like to play their god-like games with the beings who inhabit it. Meddling, influencing, demanding...you know, the stuff god's do. One of these factors for their entertainment is randomly (is it really random though?) marking the odd being with a rune mark on their body. The beings who are "rune born" are referred to as "rune marked" and that may or may not be a good thing depending on where in the world you visit and with whom you let know that you are rune marked. Those born with a rune mark have powers, abilities, intelligence, skills and the like that allow them to be... "more" than everyone else. Naturally there are those who would despise you for being better than them, or more skilled, talented, intelligent and many are outright terrified if you can harness magic as a result.
As such, in this world... most rune marked tend to go about their lives in secret or band together with those who are also marked. There are communities built around being rune marked and there are secret guilds and so forth. To use a horrible analogy from our past history... think of how the Jewish have been treated. In some places... not a problem, other places... tolerated, other places... despised and hunted.
Being rune marked grants you with special talents and abilities but with it... a cost potentially. Luckily... the vast majority of the world is aware of those who are rune marked, and for every one individual out there who has hatred for them, there are hundreds who are indifferent or do not care at all.
For more on this, read up in the character creation section here